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https://doi.org/10.5194/pb-4-77-2017
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https://doi.org/10.5194/pb-4-77-2017
© Author(s) 2017. This work is distributed under
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the Creative Commons Attribution 3.0 License.
Research article
| 
13 Apr 2017
Research article |
| 13 Apr 2017
Morphological and immunohistochemical characterization of spontaneous endometriosis in rhesus macaques (Macaca mulatta)
Eva Gruber-Dujardin
CORRESPONDING AUTHOR
Pathology Unit, German Primate Center, 37077 Göttingen, Germany
Martina Bleyer
Pathology Unit, German Primate Center, 37077 Göttingen, Germany
Kerstin Mätz-Rensing
Pathology Unit, German Primate Center, 37077 Göttingen, Germany
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Martina Bleyer, Marius Kunze, Eva Gruber-Dujardin, and Kerstin Mätz-Rensing
Primate Biol., 4, 17–25, https://doi.org/10.5194/pb-4-17-2017, https://doi.org/10.5194/pb-4-17-2017, 2017
Roland Plesker, Martina Bleyer, and Kerstin Mätz-Rensing
Primate Biol., 5, 7–13, https://doi.org/10.5194/pb-5-7-2018, https://doi.org/10.5194/pb-5-7-2018, 2018
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We present a spontaneous tumor of the meninges (meningioma) in a female pig-tailed macaque (Macaca nemestrina) more than 24 years old. Clinically, the monkey displayed slow, weak, and insecure movements and poor vision. A tumorous mass was present at the floor of the cranial cavity. It compressed adjacent parts of the brain, infiltrated surrounding bones, and expanded into the throat. Microscopically, the tumor showed both meningothelial and microcystic parts.
Kerstin Mätz-Rensing and Martina Bleyer
Primate Biol., 4, 229–230, https://doi.org/10.5194/pb-4-229-2017, https://doi.org/10.5194/pb-4-229-2017, 2017
Kerstin Mätz-Rensing, Constanze Yue, Jeanette Klenner, Heinz Ellerbrok, and Christiane Stahl-Hennig
Primate Biol., 4, 163–171, https://doi.org/10.5194/pb-4-163-2017, https://doi.org/10.5194/pb-4-163-2017, 2017
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The research into therapeutic agents for prevention and treatment of orthopoxvirus (OPXV) infections requires adequate animal models to investigate the efficacy and safety of new vaccines and antiviral compounds against smallpox and other highly pathogenic OPXVs. This study was undertaken to investigate the susceptibility of rhesus monkeys towards the calpox virus, an orthopoxvirus of the species Cowpox virus, which is uniformly lethal in common marmosets, in order to define a new animal model.
Matthias Mietsch, Ulrike Sauermann, Kerstin Mätz-Rensing, Antonina Klippert, Maria Daskalaki, Nicole Stolte-Leeb, and Christiane Stahl-Hennig
Primate Biol., 4, 107–115, https://doi.org/10.5194/pb-4-107-2017, https://doi.org/10.5194/pb-4-107-2017, 2017
Nicole Cichon, Karen Lampe, Felix Bremmer, Tamara Becker, and Kerstin Mätz-Rensing
Primate Biol., 4, 71–75, https://doi.org/10.5194/pb-4-71-2017, https://doi.org/10.5194/pb-4-71-2017, 2017
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We herein report a unique case of granulomatous arteritis in a grey mouse lemur affecting multiple organs, which is not comparable to other disease entities formerly described in nonhuman primates. The features of the entity most closely resemble disseminated visceral giant cell arteritis in humans. A concise description of the disease is given, and the differential diagnoses are discussed. An idiopathic pathogenesis is suspected.
Karen Lampe, Jens-Christian Rudnick, Fabian Leendertz, Martina Bleyer, and Kerstin Mätz-Rensing
Primate Biol., 4, 39–46, https://doi.org/10.5194/pb-4-39-2017, https://doi.org/10.5194/pb-4-39-2017, 2017
Tamara Becker, Florian Pieper, David Liebetanz, Martina Bleyer, Annette Schrod, Kerstin Maetz-Rensing, and Stefan Treue
Primate Biol., 4, 27–32, https://doi.org/10.5194/pb-4-27-2017, https://doi.org/10.5194/pb-4-27-2017, 2017
Martina Bleyer, Marius Kunze, Eva Gruber-Dujardin, and Kerstin Mätz-Rensing
Primate Biol., 4, 17–25, https://doi.org/10.5194/pb-4-17-2017, https://doi.org/10.5194/pb-4-17-2017, 2017
Antonina Klippert, Martina Bleyer, Ulrike Sauermann, Berit Neumann, Artur Kaul, Maria Daskalaki, Nicole Stolte-Leeb, Frank Kirchhoff, and Christiane Stahl-Hennig
Primate Biol., 3, 65–75, https://doi.org/10.5194/pb-3-65-2016, https://doi.org/10.5194/pb-3-65-2016, 2016
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Despite effective antiviral therapy, HIV infection frequently leads to blood cell tumors known as lymphoma in the final disease stage. We have observed the same tumors in monkeys infected with simian immunodeficiency virus. Tumor development coincided with and was fostered by co-infection with the tumorigenic simian homolog to human Epstein–Barr virus. Two cases of lymphoma are presented, one exhibiting an unusual cell surface marker composition and the other obstructing the urogenital tract.
N. Siskos, K. Lampe, F.-J. Kaup, and K. Mätz-Rensing
Primate Biol., 2, 9–12, https://doi.org/10.5194/pb-2-9-2015, https://doi.org/10.5194/pb-2-9-2015, 2015
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In this paper, a co-infection with Toxoplasma gondii and Capillaria hepatica in a ring-tailed lemur is described. As a protozoan parasite, T. gondii can affect nearly all warm-blooded species, causing toxoplasmosis. In lemurs, toxoplasmosis has severe clinical manifestations leading to death. C. hepatica also affects a broad range of mammals, causing hepatic capillariasis. Although it is not known to be lethal, its potential predisposition to toxoplasmosis in our case is of great interest.
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Spontaneous (Hashimoto-like) chronic lymphocytic thyroiditis in a rhesus macaque (Macaca mulatta)
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A review on ocular findings in mouse lemurs: potential links to age and genetic background
Spontaneous endometriosis in rhesus macaques: evidence for a genetic association with specific Mamu-A1 alleles
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Unique case of disseminated toxoplasmosis and concurrent hepatic capillariasis in a ring-tailed lemur: first case description
Roland Plesker and Kernt Köhler
Primate Biol., 10, 1–6, https://doi.org/10.5194/pb-10-1-2023, https://doi.org/10.5194/pb-10-1-2023, 2023
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To our knowledge, this report represents the first description of thyroid gland tumors in an African Green Monkey (Chlorocebus aethiops). Two cystadenomas as well as a solid follicular adenoma are described in a 27-year-old female. No indications of excessive hormone production due to the tumors were detected.
Roland Plesker and Gudrun Hintereder
Primate Biol., 8, 37–42, https://doi.org/10.5194/pb-8-37-2021, https://doi.org/10.5194/pb-8-37-2021, 2021
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To our knowledge, this study is the first report of spontaneous Hashimoto-like chronic lymphocytic thyroiditis in a rhesus macaque (Macaca mulatta). Despite the microscopic similarities to human cases, autoantibodies (thyroglobulin antibodies, thyriod peroxidase antibodies, and thyroid-stimulating hormone receptor antibodies) were not identified in this rhesus macaque using a human electrochemiluminescence immunoassay system.
Roland Plesker, Kernt Köhler, Susanne von Gerlach, Klaus Boller, Markus Vogt, and Inke S. Feder
Primate Biol., 7, 5–12, https://doi.org/10.5194/pb-7-5-2020, https://doi.org/10.5194/pb-7-5-2020, 2020
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This report describes a reactive mesothelial hyperplasia as a reaction to a polyserositis in an African green monkey (Chlorocebus aethiops) mimicking an epitheloid mesothelioma. Histopathology, immunohistochemistry, fluorescence in situ hybridization, and electron microscopy were used to determine the benign nature of the mesothelial proliferation. For the first time, human genetic probes had been successfully applied to an African green monkey.
Roland Plesker, Martina Bleyer, and Kerstin Mätz-Rensing
Primate Biol., 5, 7–13, https://doi.org/10.5194/pb-5-7-2018, https://doi.org/10.5194/pb-5-7-2018, 2018
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We present a spontaneous tumor of the meninges (meningioma) in a female pig-tailed macaque (Macaca nemestrina) more than 24 years old. Clinically, the monkey displayed slow, weak, and insecure movements and poor vision. A tumorous mass was present at the floor of the cranial cavity. It compressed adjacent parts of the brain, infiltrated surrounding bones, and expanded into the throat. Microscopically, the tumor showed both meningothelial and microcystic parts.
Marko Dubicanac, Ute Radespiel, and Elke Zimmermann
Primate Biol., 4, 215–228, https://doi.org/10.5194/pb-4-215-2017, https://doi.org/10.5194/pb-4-215-2017, 2017
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This review shows that mouse lemurs show various ocular impairments which may distort vision. The most widespread and obvious ocular finding were nuclear sclerosis and cataracts. Both highly increase with increasing age. Iris posterior synechia has been described in different colonies and seems highly age dependent and cataract associated. Combined with the variety of many other eye diseases, special ophthalmological treatments and examinations are required to ensure animal well-being.
Ivanela Kondova, Gerco Braskamp, Peter J. Heidt, Wim Collignon, Tom Haaksma, Nanine de Groot, Nel Otting, Gaby Doxiadis, Susan V. Westmoreland, Eric J. Vallender, and Ronald E. Bontrop
Primate Biol., 4, 117–125, https://doi.org/10.5194/pb-4-117-2017, https://doi.org/10.5194/pb-4-117-2017, 2017
Nicole Cichon, Karen Lampe, Felix Bremmer, Tamara Becker, and Kerstin Mätz-Rensing
Primate Biol., 4, 71–75, https://doi.org/10.5194/pb-4-71-2017, https://doi.org/10.5194/pb-4-71-2017, 2017
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We herein report a unique case of granulomatous arteritis in a grey mouse lemur affecting multiple organs, which is not comparable to other disease entities formerly described in nonhuman primates. The features of the entity most closely resemble disseminated visceral giant cell arteritis in humans. A concise description of the disease is given, and the differential diagnoses are discussed. An idiopathic pathogenesis is suspected.
Dina Kleinlützum and Roland Plesker
Primate Biol., 4, 33–37, https://doi.org/10.5194/pb-4-33-2017, https://doi.org/10.5194/pb-4-33-2017, 2017
Karen Lampe, Jens-Christian Rudnick, Fabian Leendertz, Martina Bleyer, and Kerstin Mätz-Rensing
Primate Biol., 4, 39–46, https://doi.org/10.5194/pb-4-39-2017, https://doi.org/10.5194/pb-4-39-2017, 2017
Martina Bleyer, Marius Kunze, Eva Gruber-Dujardin, and Kerstin Mätz-Rensing
Primate Biol., 4, 17–25, https://doi.org/10.5194/pb-4-17-2017, https://doi.org/10.5194/pb-4-17-2017, 2017
M. Brack
Primate Biol., 2, 81–87, https://doi.org/10.5194/pb-2-81-2015, https://doi.org/10.5194/pb-2-81-2015, 2015
F.-J. Kaup
Primate Biol., 2, 57–63, https://doi.org/10.5194/pb-2-57-2015, https://doi.org/10.5194/pb-2-57-2015, 2015
N. Siskos, K. Lampe, F.-J. Kaup, and K. Mätz-Rensing
Primate Biol., 2, 9–12, https://doi.org/10.5194/pb-2-9-2015, https://doi.org/10.5194/pb-2-9-2015, 2015
Short summary
Short summary
In this paper, a co-infection with Toxoplasma gondii and Capillaria hepatica in a ring-tailed lemur is described. As a protozoan parasite, T. gondii can affect nearly all warm-blooded species, causing toxoplasmosis. In lemurs, toxoplasmosis has severe clinical manifestations leading to death. C. hepatica also affects a broad range of mammals, causing hepatic capillariasis. Although it is not known to be lethal, its potential predisposition to toxoplasmosis in our case is of great interest.
Cited articles
Abrao, M. S., Neme, R. M., Carvalho, F. M., Aldrighi, J. M., and Pinotti, J. A.: Histological classification of endometriosis as a predictor of response to treatment, Int. J. Gynaecol. Obstet., 82, 31–40, 2003.
Adamson, G. D.: Endometriosis classification: an update, Curr. Opin. Obstet. Gyn., 23, 213–220, https://doi.org/10.1097/GCO.0b013e328348a3ba, 2011.
Allred, D. C., Harvey, J. M., Berardo, M. D., and Clark, G. M.: Prognostic and predictive factors in breast cancer by immunohistochemical analysis, Mod Pathol, 11, 155–168, 1998.
Assaf, B. T. and Miller, A. D.: Pleural endometriosis in an aged rhesus macaque (Macaca mulatta): a histopathologic and immunohistochemical study, Vet. Pathol., 49, 636–641, https://doi.org/10.1177/0300985811406890, 2012.
Atkins, H. M., Lombardini, E. D., Caudell, D. L., Appt, S. E., Dubois, A., and Cline, J. M.: Decidualization of Endometriosis in Macaques, Vet. Pathol., 53, 1252–1258, https://doi.org/10.1177/0300985816646433, 2016.
Barnhart, K., Dunsmoor-Su, R., and Coutifaris, C.: Effect of endometriosis on in vitro fertilization, Fertil. Steril., 77, 1148–1155, 2002.
Barrier, B. F., Allison, J., Hubbard, G. B., Dick Jr., E. J., Brasky, K. M., and Schust, D. J.: Spontaneous adenomyosis in the chimpanzee (Pan troglodytes): a first report and review of the primate literature: case report, Human reproduction (Oxford, England), 22, 1714–1717, https://doi.org/10.1093/humrep/dem038, 2007.
Baskin, G. B., Smith, S. M., and Marx, P. A.: Endometrial hyperplasia, polyps, and adenomyosis associated with unopposed estrogen in rhesus monkeys (Macaca mulatta), Vet. Pathol., 39, 572–575, 2002.
Batt, R. E., Smith, R. A., Buck, G. M., Severino, M. F., and Naples, J. D.: Mullerianosis, Prog. Clin. Biol. Res., 323, 413–426, 1990.
Beck, A. P., Erdelyi, I., and Zeiss, C. J.: Endometrial decidualization and deciduosis in aged rhesus macaques (Macaca mulatta), Comp. Med., 64, 148–156, 2014.
Bennett, M. W., Dick Jr., E. J., Schlabritz-Loutsevitch, N. E., Lopez-Alvarenga, J. C., Williams, P. C., Sharp, R. M., and Hubbard, G. B.: Endometrial and cervical polyps in 22 baboons (Papio sp.), 5 cynomolgus macaques (Macaca fascicularis) and one marmoset (Callithrix jacchus), J. Med. Primatol., 38, 257–262, https://doi.org/10.1111/j.1600-0684.2009.00350.x, 2009.
Bielefeldt-Ohmann, H., Barouch, D. H., Bakke, A. M., Bruce, A. G., Durning, M., Grant, R., Letvin, N. L., Ryan, J. T., Schmidt, A., Thouless, M. E., and Rose, T. M.: Intestinal stromal tumors in a simian immunodeficiency virus-infected, simian retrovirus-2 negative rhesus macaque (Macaca mulatta), Vet. Pathol., 42, 391–396, https://doi.org/10.1354/vp.42-3-391, 2005.
Bischoff, F. Z. and Simpson, J. L.: Heritability and molecular genetic studies of endometriosis, Hum. Reprod. Update, 6, 37–44, 2000.
Borghese, B., Zondervan, K. T., Abrao, M. S., Chapron, C., and Vaiman, D.: recent insights on the genetics and epigenetics of endometriosis, Clin. Genet., 91, 254–264, https://doi.org/10.1111/cge.12897, 2016.
Braundmeier, A. G. and Fazleabas, A. T.: The non-human primate model of endometriosis: research and implications for fecundity, Mol. Hum. Reprod., 15, 577–586, https://doi.org/10.1093/molehr/gap057, 2009.
Brosens, I., Gargett, C. E., Guo, S.-W., Puttemans, P., Gordts, S., Brosens, J. J., and Benagiano, G.: Origins and Progression of Adolescent Endometriosis, Reprod. Sci., 23, 1282–1288, https://doi.org/10.1177/1933719116637919, 2016.
Brosens, I. A. and Brosens, J. J.: Redefining endometriosis: is deep endometriosis a progressive disease?, Human reproduction (Oxford, England), 15, 1–3, 2000a.
Brosens, I. A. and Brosens, J. J.: Endometriosis, Eur. J. Obstet. Gyn. R. B., 90, 159–164, 2000b.
Burns, P. A., Kemp, C. J., Gannon, J. V., Lane, D. P., Bremner, R., and Balmain, A.: Loss of heterozygosity and mutational alterations of the p53 gene in skin tumours of interspecific hybrid mice, Oncogene, 6, 2363–2369, 1991.
Carmona, R., Cano, E., Grueso, E., Ruiz-Villalba, A., Bera, T. K., Gaztambide, J., Segovia, J. C., and Muñoz-Chápuli, R.: Peritoneal repairing cells: a type of bone marrow derived progenitor cells involved in mesothelial regeneration, J. Cell. Mol. Med., 15, 1200–1209, https://doi.org/10.1111/j.1582-4934.2010.01087.x, 2011.
Coe, C. L., Lemieux, A. M., Rier, S. E., Uno, H., and Zimbric, M. L.: Profile of endometriosis in the aging female rhesus monkey, J. Gerontol. A Biol. Sci. Med. Sci., 53, 3–7, 1998.
D'Hooghe, T. M. and Debrock, S.: Endometriosis, retrograde menstruation and peritoneal inflammation in women and in baboons, Hum. Reprod. Update, 8, 84–88, https://doi.org/10.1093/humupd/8.1.84, 2002.
Defrere, S., Lousse, J. C., Gonzalez-Ramos, R., Colette, S., Donnez, J., and Van Langendonckt, A.: Potential involvement of iron in the pathogenesis of peritoneal endometriosis, Mol. Hum. Reprod., 14, 377–385, https://doi.org/10.1093/molehr/gan033, 2008a.
Defrere, S., Squifflet, J., Lousse, J. C., Van Langendonckt, A., Gonzalez-Ramos, R., Foidart, J. M., Jerome, C., Delattre, L., Donnez, J., and Dehoux, J. P.: Unsuccessful induction of endometriosis in female rhesus macaques (Macaca mulatta), Gynecol. Obstet. Invest., 66, 84–90, https://doi.org/10.1159/000127447, 2008b.
Dick Jr., E. J., Hubbard, G. B., Martin, L. J., and Leland, M. M.: Record review of baboons with histologically confirmed endometriosis in a large established colony, J. Med. Primatol., 32, 39–47, 2003.
Dinulescu, D. M., Ince, T. A., Quade, B. J., Shafer, S. A., Crowley, D., and Jacks, T.: Role of K-ras and Pten in the development of mouse models of endometriosis and endometrioid ovarian cancer, Nat. Med., 11, 63–70, https://doi.org/10.1038/nm1173, 2005.
Einspanier, A., Lieder, K., Bruns, A., Husen, B., Thole, H., and Simon, C.: Induction of endometriosis in the marmoset monkey (Callithrix jacchus), Mol. Hum. Reprod., 12, 291–299, https://doi.org/10.1093/molehr/gal031, 2006.
Fanton, J. W., Hubbard, G. B., and Wood, D. H.: Endometriosis: clinical and pathologic findings in 70 rhesus monkeys, Am. J. Vet. Res., 47, 1537–1541, 1986.
Fassina, A., Cappellesso, R., Guzzardo, V., Dalla Via, L., Piccolo, S., Ventura, L., and Fassan, M.: Epithelial-mesenchymal transition in malignant mesothelioma, Mod. Pathol., 25, 86–99, https://doi.org/10.1038/modpathol.2011.144, 2012.
Fazleabas, A. T., Brudney, A., Gurates, B., Chai, D., and Bulun, S.: A modified baboon model for endometriosis, Ann. NY. Acad. Sci., 955, 308–317, 2002.
Fazleabas, A. T., Brudney, A., Chai, D., Langoi, D., and Bulun, S. E.: Steroid receptor and aromatase expression in baboon endometriotic lesions, Fertil. Steril., 80, 820–827, 2003.
Ferreira, E., Gobbi, H., Saraiva, B. S., and Cassali, G. D.: Histological and Immunohistochemical Identification of Atypical Ductal Mammary Hyperplasia as a Preneoplastic Marker in Dogs, Veterinary Pathology Online, 49, 322–329, https://doi.org/10.1177/0300985810396105, 2012.
Figueira, P. G., Abrao, M. S., Krikun, G., and Taylor, H. S.: Stem cells in endometrium and their role in the pathogenesis of endometriosis, Ann. NY. Acad. Sci., 1221, 10–17, https://doi.org/10.1111/j.1749-6632.2011.05969.x, 2011.
Fikes, J. D. and O'Sullivan, M. G.: Localized retroperitoneal fibromatosis causing intestinal obstruction in a cynomolgus monkey (Macaca fascicularis), Vet. Pathol., 32, 713–716, 1995.
Forte, A., Schettino, M. T., Finicelli, M., Cipollaro, M., Colacurci, N., Cobellis, L., and Galderisi, U.: Expression pattern of stemness-related genes in human endometrial and endometriotic tissues, Mol. Med., 15, 392–401, https://doi.org/10.2119/molmed.2009.00068, 2009.
Forte, A., Cipollaro, M., and Galderisi, U.: Genetic, epigenetic and stem cell alterations in endometriosis: new insights and potential therapeutic perspectives, Clin. Sci. (Lond.), 126, 123–138, https://doi.org/10.1042/CS20130099, 2014.
Gargett, C. E., Schwab, K. E., and Deane, J. A.: Endometrial stem/progenitor cells: the first 10 years, Hum. Reprod. Update, 22, 137–163, https://doi.org/10.1093/humupd/dmv051, 2016.
Gashaw, I., Hastings, J. M., Jackson, K. S., Winterhager, E., and Fazleabas, A. T.: Induced endometriosis in the baboon (Papio anubis) increases the expression of the proangiogenic factor CYR61 (CCN1) in eutopic and ectopic endometria, Biol. Reprod., 74, 1060–1066, https://doi.org/10.1095/biolreprod.105.049320, 2006.
Giudice, L. C. and Kao, L. C.: Endometriosis, Lancet, 364, 1789–1799, https://doi.org/10.1016/S0140-6736(04)17403-5, 2004.
Gotloib, L., Gotloib, L. C., and Khrizman, V.: The use of peritoneal mesothelium as a potential source of adult stem cells, Int. J. Artif. Organs, 30, 501–512, 2007.
Gotte, M., Wolf, M., Staebler, A., Buchweitz, O., Kiesel, L., and Schuring, A. N.: Aberrant expression of the pluripotency marker SOX-2 in endometriosis, Fertil. Steril., 95, 338–341, https://doi.org/10.1016/j.fertnstert.2010.08.006, 2011.
Greaves, P. and White, I. N.: Experimental adenomyosis, Best Pract. Res. Clin. Obstet. Gynaecol., 20, 503–510, https://doi.org/10.1016/j.bpobgyn.2006.01.003, 2006.
Gruenwald, P.: Origin of endometriosis from the mesenchyme of the celomic walls, Am. J. Obstet. Gynecol., 44, 470–474, https://doi.org/10.1016/S0002-9378(42)90484-8, 1942.
Grummer, R.: Animal models in endometriosis research, Hum. Reprod. Update, 12, 641–649, https://doi.org/10.1093/humupd/dml026, 2006.
Harlozinska, A., Bar, J. K., Sedlaczek, P., and Gerber, J.: Expression of p53 protein and Ki-67 reactivity in ovarian neoplasms, Correlation with histopathology, Am. J. Clin. Pathol., 105, 334–340, 1996.
Harp, D., Driss, A., Mehrabi, S., Chowdhury, I., Xu, W., Liu, D., Garcia-Barrio, M., Taylor, R. N., Gold, B., Jefferson, S., Sidell, N., and Thompson, W.: Exosomes derived from endometriotic stromal cells have enhanced angiogenic effects in vitro, Cell Tissue Res., 365, 187–196, https://doi.org/10.1007/s00441-016-2358-1, 2016.
Harvey, J. M., Clark, G. M., Osborne, C. K., and Allred, D.C.: Estrogen receptor status by immunohistochemistry is superior to the ligandbinding assay for predicting response to adjuvant endocrine therapy in breast cancer, J. Clin. Oncol., 17, 1474–1481, 1999.
Higashiura, Y., Kajihara, H., Shigetomi, H., and Kobayashi, H.: Identification of multiple pathways involved in the malignant transformation of endometriosis (Review), Oncol Lett., 4, 3–9, https://doi.org/10.3892/ol.2012.690, 2012.
Kamergorodsky, G., Ribeiro, P. A., Galvão, M. A., Abrão, M. S., Donadio, N., Lemos, N. L., and Aoki, T.: Histologic classification of specimens from women affected by superficial endometriosis, deeply infiltrating endometriosis, and ovarian endometriomas, Fertil. Steril., 92, 2074–2077, https://doi.org/10.1016/j.fertnstert.2009.05.086, 2009.
Kinra, P., Sen, A., and Sharma, J. C.: Ectopic Decidual Reaction: A Case Report, Med. J. Armed. Forces India, 62, 280–281, https://doi.org/10.1016/S0377-1237(06)80022-5, 2006.
Kobayashi, H.: Invasive Capacity of Heterotopic Endometrium, Gynecol. Obstet. Inves., 50, 26–32, 2000.
Lousse, J. C., Defrere, S., Van Langendonckt, A., Gras, J., Gonzalez-Ramos, R., Colette, S., and Donnez, J.: Iron storage is significantly increased in peritoneal macrophages of endometriosis patients and correlates with iron overload in peritoneal fluid, Fertil. Steril., 91, 1668–1675, https://doi.org/10.1016/j.fertnstert.2008.02.103, 2009.
MacKenzie, W. F. and Casey, H. W.: Animal model of human disease. Endometriosis, Animal model: endometriosis in rhesus monkeys, Am. J. Pathol., 80, 341–344, 1975.
Mahmood, T. A. and Templeton, A.: Prevalence and genesis of endometriosis, Human reproduction (Oxford, England), 6, 544–549, 1991.
Mandai, M., Yamaguchi, K., Matsumura, N., Baba, T., and Konishi, I.: Ovarian cancer in endometriosis: molecular biology, pathology, and clinical management, Int. J. Clin. Oncol., 14, 383–391, https://doi.org/10.1007/s10147-009-0935-y, 2009.
Marston, J. H., Kelly, W. A., and Eckstein, P.: Deciduomal reaction induced in rhesus monkeys by tubal injection of arachis oil and by the presence of an intrauterine device, J. Reprod. Fertil., 25, 451–454, 1971.
Marx, P. A. and Lowenstine, L. J.: Mesenchymal neoplasms associated with type D retroviruses in macaques, Cancer Surv., 6, 101–115, 1987.
Matsuzaki, S. and Darcha, C.: Epithelial to mesenchymal transition-like and mesenchymal to epithelial transition-like processes might be involved in the pathogenesis of pelvic endometriosis, Human reproduction (Oxford, England), 27, 712–721, https://doi.org/10.1093/humrep/der442, 2012.
Matthai, C., Horvat, R., Noe, M., Nagele, F., Radjabi, A., van Trotsenburg, M., Huber, J., and Kolbus, A.: Oct-4 expression in human endometrium, Mol. Hum. Reprod., 12, 7–10, https://doi.org/10.1093/molehr/gah254, 2006.
Mattison, J. A., Ottinger, M. A., Powell, D., Longo, D. L., and Ingram, D. K.: Endometriosis: clinical monitoring and treatment procedures in Rhesus Monkeys, J. Med. Primatol., 36, 391–398, https://doi.org/10.1111/j.1600-0684.2006.00208.x, 2007.
Mehedintu, C., Plotogea, M., Ionescu, S., and Antonovici, M.: Endometriosis still a challenge, Journal of Medicine and Life, 7, 349–357, 2014.
Mounsey, A. L., Wilgus, A., and Slawson, D. C.: Diagnosis and management of endometriosis, Am. Fam. Physician, 74, 594–600, 2006.
Mutsaers, S. E., Birnie, K., Lansley, S., Herrick, S. E., Lim, C.-B., and Prêle, C. M.: Mesothelial cells in tissue repair and fibrosis, Frontiers in Pharmacology, 6, 1–12, https://doi.org/10.3389/fphar.2015.00113, 2015.
Nezhat, F., Datta, M. S., Hanson, V., Pejovic, T., Nezhat, C., and Nezhat, C.: The relationship of endometriosis and ovarian malignancy: a review, Fertil. Steril., 90, 1559–1570, https://doi.org/10.1016/j.fertnstert.2008.08.007, 2008.
Nishida, M., Watanabe, K., Sato, N., and Ichikawa, Y.: Malignant transformation of ovarian endometriosis, Gynecol. Obstet. Invest., 50, 18–25, 2000.
O'Leary, S. M.: Ectopic decidualization causing massive postpartum intraperitoneal hemorrhage, Obstet. Gynecol., 108, 776–779, https://doi.org/10.1097/01.AOG.0000200596.98039.c5, 2006.
Olivennes, F.: [Results of IVF in women with endometriosis], J Gynecol Obstet Biol Reprod (Paris), 32, S45-47, 2003.
Pinkert, T. C., Catlow, C. E., and Straus, R.: Endometriosis of the urinary bladder in a man with prostatic carcinoma, Cancer, 43, 1562–1567, https://doi.org/10.1002/1097-0142(197904)43:4<1562::AID-CNCR2820430451>3.0.CO;2-W, 1979.
Porto, B. T., Ribeiro, H. S., Galvão, M. A., Sekula, V. G., Aldrigui, J. M., and Ribeiro, P. A.: Histological classification and quality of life in women with endometriosis, Rev. Bras. Ginecol. Obstet., 37, 87–93, https://doi.org/10.1590/SO100-720320140004650, 2015 (in Portuguese).
Rier, S. E., Martin, D. C., Bowman, R. E., Dmowski, W. P., and Becker, J. L.: Endometriosis in rhesus monkeys (Macaca mulatta) following chronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin, Fundam. Appl. Toxicol., 21, 433–441, 1993.
Rose, T. M., Strand, K. B., Schultz, E. R., Schaefer, G., Rankin, G. W., Jr., Thouless, M. E., Tsai, C. C., and Bosch, M. L.: Identification of two homologs of the Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in retroperitoneal fibromatosis of different macaque species, J. Virol., 71, 4138–4144, 1997.
Sampson, J. A.: Peritoneal endometriosis due to the menstrual dissemination of endometrial tissue into the peritoneal cavity, Am. J. Obstet. Gynecol., 14, 422–469, https://doi.org/10.1016/S0002-9378(15)30003-X, 1927.
Sasson, I. E. and Taylor, H. S.: Stem cells and the pathogenesis of endometriosis, Ann. NY. Acad. Sci., 1127, 106–115, https://doi.org/10.1196/annals.1434.014, 2008.
Schindler, A. E.: Epidemiologie, Pathogenese und Diagnostik der Endometriose, Journal für Fertilität und Reproduktion, 17, 22–27, 2007.
Schrodt, G. R., Alcorn, M. O., and Ibanez, J.: Endometriosis of the male urinary system: a case report, J. Urol., 124, 722–723, 1980.
Scotti, S., Regidor, P. A., Schindler, A. E., and Winterhager, E.: Reduced proliferation and cell adhesion in endometriosis, Mol. Hum. Reprod., 6, 610–617, 2000.
Shia, J., Erlandson, R. A., and Klimstra, D. S.: Deciduoid mesothelioma: a report of 5 cases and literature review, Ultrastruct Pathol., 26, 355–363, https://doi.org/10.1080/0913120290104647, 2002.
Slayden, O. D. and Brenner, R. M.: Hormonal regulation and localization of estrogen, progestin and androgen receptors in the endometrium of nonhuman primates: effects of progesterone receptor antagonists, Arch. Histol. Cytol., 67, 393–409, 2004.
Surget, S., Khoury, M. P., and Bourdon, J. C.: Uncovering the role of p53 splice variants in human malignancy: a clinical perspective, Onco Targets Ther., 7, 57–68, https://doi.org/10.2147/OTT.S53876, 2013.
Taketani, Y., Kuo, T. M., and Mizuno, M.: Comparison of cytokine levels and embryo toxicity in peritoneal fluid in infertile women with untreated or treated endometriosis, Am. J. Obstet. Gynecol., 167, 265–270, 1992.
Tanase, Y., Furukawa, N., Kobayashi, H., and Matsumoto, T.: Malignant Transformation from Endometriosis to Atypical Endometriosis and Finally to Endometrioid Adenocarcinoma within 10 Years, Case Rep. Oncol., 6, 480–484, https://doi.org/10.1159/000355282, 2013.
Thomas, E. J. and Campbell, I. G.: Molecular genetic defects in endometriosis, Gynecol. Obstet. Invest., 50, 44–50, 2000.
Toki, T. and Nakayama, K.: Proliferative Activity and Genetic Alterations in TP53 in Endometriosis, Gynecol. Obstet. Inves., 50, 33–38, 2000.
Van Esch, E., Cline, J. M., Buse, E., and Weinbauer, G. F.: The Macaque Endometrium, with Special Reference to the Cynomolgus Monkey (Macaca fascicularis), Toxicologic Pathology, 36, 67S–100S, https://doi.org/10.1177/0192623308326149, 2008.
Van Patten, K., Parkash, V., and Jain, D.: Cadherin expression in gastrointestinal tract endometriosis: possible role in deep tissue invasion and development of malignancy, Mod. Pathol., 23, 38–44, https://doi.org/10.1038/modpathol.2009.127, 2010.
Wadsworth, P. F., Lewis, D. J., and Heywood, R.: The ultrastructural features of progestagen-induced decidual cells in the rhesus monkey (Macaca mulatta), Contraception, 22, 189–198, 1980.
Webber, J. P., Spary, L. K., Sanders, A. J., Chowdhury, R., Jiang, W. G., Steadman, R., Wymant, J., Jones, A. T., Kynaston, H., Mason, M. D., Tabi, Z., and Clayton, A.: Differentiation of tumour-promoting stromal myofibroblasts by cancer exosomes, Oncogene, 34, 290–302, https://doi.org/10.1038/onc.2013.560, 2015.
Wilkinson, M., Walters, S., Smith, T., and Wilkinson, A.: Reproductive abnormalities in aged female Macaca fascicularis, J Med Primatol, 37, 88–93, https://doi.org/10.1111/j.1600-0684.2007.00268.x, 2008.
Yoshikawa, H., Jimbo, H., Okada, S., Matsumoto, K., Onda, T., Yasugi, T., and Taketani, Y.: Prevalence of Endometriosis in Ovarian Cancer, Gynecol. Obstet. Inves., 50, 11–17, 2000.
Young, V. J., Brown, J. K., Saunders, P. T. K., and Horne, A. W.: The role of the peritoneum in the pathogenesis of endometriosis, Hum. Reprod. Update, 19, 558–569, https://doi.org/10.1093/humupd/dmt024, 2013.
Zondervan, K. T., Weeks, D. E., Colman, R., Cardon, L. R., Hadfield, R., Schleffler, J., Trainor, A. G., Coe, C. L., Kemnitz, J. W., and Kennedy, S. H.: Familial aggregation of endometriosis in a large pedigree of rhesus macaques, Human reproduction (Oxford, England), 19, 448–455, 2004.
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