Articles | Volume 4, issue 1
https://doi.org/10.5194/pb-4-39-2017
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the Creative Commons Attribution 3.0 License.
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https://doi.org/10.5194/pb-4-39-2017
© Author(s) 2017. This work is distributed under
the Creative Commons Attribution 3.0 License.
the Creative Commons Attribution 3.0 License.
Research article
| 
08 Mar 2017
Research article |
| 08 Mar 2017
Intravascular T-cell lymphoma in a patas monkey (Erythrocebus patas)
Karen Lampe
CORRESPONDING AUTHOR
Pathology Unit, German Primate Center, Leibniz-Institute for
Primate Research, Kellnerweg 4, 37077 Göttingen, Germany
Jens-Christian Rudnick
Tierklinik-Tierheim GmbH Rostock, Thierfelderstraße 19, 18059
Rostock, Germany
Fabian Leendertz
Robert Koch Institut, Nordufer 20, 13353 Berlin, Germany
Martina Bleyer
Pathology Unit, German Primate Center, Leibniz-Institute for
Primate Research, Kellnerweg 4, 37077 Göttingen, Germany
Kerstin Mätz-Rensing
Pathology Unit, German Primate Center, Leibniz-Institute for
Primate Research, Kellnerweg 4, 37077 Göttingen, Germany
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Nicole Cichon, Karen Lampe, Felix Bremmer, Tamara Becker, and Kerstin Mätz-Rensing
Primate Biol., 4, 71–75, https://doi.org/10.5194/pb-4-71-2017, https://doi.org/10.5194/pb-4-71-2017, 2017
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We herein report a unique case of granulomatous arteritis in a grey mouse lemur affecting multiple organs, which is not comparable to other disease entities formerly described in nonhuman primates. The features of the entity most closely resemble disseminated visceral giant cell arteritis in humans. A concise description of the disease is given, and the differential diagnoses are discussed. An idiopathic pathogenesis is suspected.
Roland Plesker, Martina Bleyer, and Kerstin Mätz-Rensing
Primate Biol., 5, 7–13, https://doi.org/10.5194/pb-5-7-2018, https://doi.org/10.5194/pb-5-7-2018, 2018
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We present a spontaneous tumor of the meninges (meningioma) in a female pig-tailed macaque (Macaca nemestrina) more than 24 years old. Clinically, the monkey displayed slow, weak, and insecure movements and poor vision. A tumorous mass was present at the floor of the cranial cavity. It compressed adjacent parts of the brain, infiltrated surrounding bones, and expanded into the throat. Microscopically, the tumor showed both meningothelial and microcystic parts.
Kerstin Mätz-Rensing and Martina Bleyer
Primate Biol., 4, 229–230, https://doi.org/10.5194/pb-4-229-2017, https://doi.org/10.5194/pb-4-229-2017, 2017
Kerstin Mätz-Rensing, Constanze Yue, Jeanette Klenner, Heinz Ellerbrok, and Christiane Stahl-Hennig
Primate Biol., 4, 163–171, https://doi.org/10.5194/pb-4-163-2017, https://doi.org/10.5194/pb-4-163-2017, 2017
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The research into therapeutic agents for prevention and treatment of orthopoxvirus (OPXV) infections requires adequate animal models to investigate the efficacy and safety of new vaccines and antiviral compounds against smallpox and other highly pathogenic OPXVs. This study was undertaken to investigate the susceptibility of rhesus monkeys towards the calpox virus, an orthopoxvirus of the species Cowpox virus, which is uniformly lethal in common marmosets, in order to define a new animal model.
Matthias Mietsch, Ulrike Sauermann, Kerstin Mätz-Rensing, Antonina Klippert, Maria Daskalaki, Nicole Stolte-Leeb, and Christiane Stahl-Hennig
Primate Biol., 4, 107–115, https://doi.org/10.5194/pb-4-107-2017, https://doi.org/10.5194/pb-4-107-2017, 2017
Eva Gruber-Dujardin, Martina Bleyer, and Kerstin Mätz-Rensing
Primate Biol., 4, 77–91, https://doi.org/10.5194/pb-4-77-2017, https://doi.org/10.5194/pb-4-77-2017, 2017
Nicole Cichon, Karen Lampe, Felix Bremmer, Tamara Becker, and Kerstin Mätz-Rensing
Primate Biol., 4, 71–75, https://doi.org/10.5194/pb-4-71-2017, https://doi.org/10.5194/pb-4-71-2017, 2017
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We herein report a unique case of granulomatous arteritis in a grey mouse lemur affecting multiple organs, which is not comparable to other disease entities formerly described in nonhuman primates. The features of the entity most closely resemble disseminated visceral giant cell arteritis in humans. A concise description of the disease is given, and the differential diagnoses are discussed. An idiopathic pathogenesis is suspected.
Hélène Marie De Nys, Therese Löhrich, Doris Wu, Sébastien Calvignac-Spencer, and Fabian Hubertus Leendertz
Primate Biol., 4, 47–59, https://doi.org/10.5194/pb-4-47-2017, https://doi.org/10.5194/pb-4-47-2017, 2017
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Humans and African great apes (AGAs) are naturally infected with several species of closely related malaria parasites. Research on AGA malaria has been driven by the need to understand the origins of human malaria and the risk of transmission of malaria parasites infecting AGAs to humans. The understanding of the ecology of AGA malaria parasites and their impact on AGA health remains relatively poor. We review current knowledge on AGA malaria and identify gaps and future research perspectives.
Tamara Becker, Florian Pieper, David Liebetanz, Martina Bleyer, Annette Schrod, Kerstin Maetz-Rensing, and Stefan Treue
Primate Biol., 4, 27–32, https://doi.org/10.5194/pb-4-27-2017, https://doi.org/10.5194/pb-4-27-2017, 2017
Martina Bleyer, Marius Kunze, Eva Gruber-Dujardin, and Kerstin Mätz-Rensing
Primate Biol., 4, 17–25, https://doi.org/10.5194/pb-4-17-2017, https://doi.org/10.5194/pb-4-17-2017, 2017
Antonina Klippert, Martina Bleyer, Ulrike Sauermann, Berit Neumann, Artur Kaul, Maria Daskalaki, Nicole Stolte-Leeb, Frank Kirchhoff, and Christiane Stahl-Hennig
Primate Biol., 3, 65–75, https://doi.org/10.5194/pb-3-65-2016, https://doi.org/10.5194/pb-3-65-2016, 2016
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Despite effective antiviral therapy, HIV infection frequently leads to blood cell tumors known as lymphoma in the final disease stage. We have observed the same tumors in monkeys infected with simian immunodeficiency virus. Tumor development coincided with and was fostered by co-infection with the tumorigenic simian homolog to human Epstein–Barr virus. Two cases of lymphoma are presented, one exhibiting an unusual cell surface marker composition and the other obstructing the urogenital tract.
N. Siskos, K. Lampe, F.-J. Kaup, and K. Mätz-Rensing
Primate Biol., 2, 9–12, https://doi.org/10.5194/pb-2-9-2015, https://doi.org/10.5194/pb-2-9-2015, 2015
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In this paper, a co-infection with Toxoplasma gondii and Capillaria hepatica in a ring-tailed lemur is described. As a protozoan parasite, T. gondii can affect nearly all warm-blooded species, causing toxoplasmosis. In lemurs, toxoplasmosis has severe clinical manifestations leading to death. C. hepatica also affects a broad range of mammals, causing hepatic capillariasis. Although it is not known to be lethal, its potential predisposition to toxoplasmosis in our case is of great interest.
Related subject area
Pathology
Multiple adenomas of the thyroid gland in an African green monkey (Chlorocebus aethiops)
Spontaneous (Hashimoto-like) chronic lymphocytic thyroiditis in a rhesus macaque (Macaca mulatta)
Reactive mesothelial hyperplasia mimicking mesothelioma in an African green monkey (Chlorocebus aethiops)
Spontaneous meningioma in a pig-tailed macaque (Macaca nemestrina)
A review on ocular findings in mouse lemurs: potential links to age and genetic background
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The Department of Pathology at the German Primate Center from 1973 to 1999
From the working group "Experimental Pathology" to the department "Pathology Unit" – historical development in retrospect
Unique case of disseminated toxoplasmosis and concurrent hepatic capillariasis in a ring-tailed lemur: first case description
Roland Plesker and Kernt Köhler
Primate Biol., 10, 1–6, https://doi.org/10.5194/pb-10-1-2023, https://doi.org/10.5194/pb-10-1-2023, 2023
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To our knowledge, this report represents the first description of thyroid gland tumors in an African Green Monkey (Chlorocebus aethiops). Two cystadenomas as well as a solid follicular adenoma are described in a 27-year-old female. No indications of excessive hormone production due to the tumors were detected.
Roland Plesker and Gudrun Hintereder
Primate Biol., 8, 37–42, https://doi.org/10.5194/pb-8-37-2021, https://doi.org/10.5194/pb-8-37-2021, 2021
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To our knowledge, this study is the first report of spontaneous Hashimoto-like chronic lymphocytic thyroiditis in a rhesus macaque (Macaca mulatta). Despite the microscopic similarities to human cases, autoantibodies (thyroglobulin antibodies, thyriod peroxidase antibodies, and thyroid-stimulating hormone receptor antibodies) were not identified in this rhesus macaque using a human electrochemiluminescence immunoassay system.
Roland Plesker, Kernt Köhler, Susanne von Gerlach, Klaus Boller, Markus Vogt, and Inke S. Feder
Primate Biol., 7, 5–12, https://doi.org/10.5194/pb-7-5-2020, https://doi.org/10.5194/pb-7-5-2020, 2020
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This report describes a reactive mesothelial hyperplasia as a reaction to a polyserositis in an African green monkey (Chlorocebus aethiops) mimicking an epitheloid mesothelioma. Histopathology, immunohistochemistry, fluorescence in situ hybridization, and electron microscopy were used to determine the benign nature of the mesothelial proliferation. For the first time, human genetic probes had been successfully applied to an African green monkey.
Roland Plesker, Martina Bleyer, and Kerstin Mätz-Rensing
Primate Biol., 5, 7–13, https://doi.org/10.5194/pb-5-7-2018, https://doi.org/10.5194/pb-5-7-2018, 2018
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We present a spontaneous tumor of the meninges (meningioma) in a female pig-tailed macaque (Macaca nemestrina) more than 24 years old. Clinically, the monkey displayed slow, weak, and insecure movements and poor vision. A tumorous mass was present at the floor of the cranial cavity. It compressed adjacent parts of the brain, infiltrated surrounding bones, and expanded into the throat. Microscopically, the tumor showed both meningothelial and microcystic parts.
Marko Dubicanac, Ute Radespiel, and Elke Zimmermann
Primate Biol., 4, 215–228, https://doi.org/10.5194/pb-4-215-2017, https://doi.org/10.5194/pb-4-215-2017, 2017
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This review shows that mouse lemurs show various ocular impairments which may distort vision. The most widespread and obvious ocular finding were nuclear sclerosis and cataracts. Both highly increase with increasing age. Iris posterior synechia has been described in different colonies and seems highly age dependent and cataract associated. Combined with the variety of many other eye diseases, special ophthalmological treatments and examinations are required to ensure animal well-being.
Ivanela Kondova, Gerco Braskamp, Peter J. Heidt, Wim Collignon, Tom Haaksma, Nanine de Groot, Nel Otting, Gaby Doxiadis, Susan V. Westmoreland, Eric J. Vallender, and Ronald E. Bontrop
Primate Biol., 4, 117–125, https://doi.org/10.5194/pb-4-117-2017, https://doi.org/10.5194/pb-4-117-2017, 2017
Eva Gruber-Dujardin, Martina Bleyer, and Kerstin Mätz-Rensing
Primate Biol., 4, 77–91, https://doi.org/10.5194/pb-4-77-2017, https://doi.org/10.5194/pb-4-77-2017, 2017
Nicole Cichon, Karen Lampe, Felix Bremmer, Tamara Becker, and Kerstin Mätz-Rensing
Primate Biol., 4, 71–75, https://doi.org/10.5194/pb-4-71-2017, https://doi.org/10.5194/pb-4-71-2017, 2017
Short summary
Short summary
We herein report a unique case of granulomatous arteritis in a grey mouse lemur affecting multiple organs, which is not comparable to other disease entities formerly described in nonhuman primates. The features of the entity most closely resemble disseminated visceral giant cell arteritis in humans. A concise description of the disease is given, and the differential diagnoses are discussed. An idiopathic pathogenesis is suspected.
Dina Kleinlützum and Roland Plesker
Primate Biol., 4, 33–37, https://doi.org/10.5194/pb-4-33-2017, https://doi.org/10.5194/pb-4-33-2017, 2017
Martina Bleyer, Marius Kunze, Eva Gruber-Dujardin, and Kerstin Mätz-Rensing
Primate Biol., 4, 17–25, https://doi.org/10.5194/pb-4-17-2017, https://doi.org/10.5194/pb-4-17-2017, 2017
M. Brack
Primate Biol., 2, 81–87, https://doi.org/10.5194/pb-2-81-2015, https://doi.org/10.5194/pb-2-81-2015, 2015
F.-J. Kaup
Primate Biol., 2, 57–63, https://doi.org/10.5194/pb-2-57-2015, https://doi.org/10.5194/pb-2-57-2015, 2015
N. Siskos, K. Lampe, F.-J. Kaup, and K. Mätz-Rensing
Primate Biol., 2, 9–12, https://doi.org/10.5194/pb-2-9-2015, https://doi.org/10.5194/pb-2-9-2015, 2015
Short summary
Short summary
In this paper, a co-infection with Toxoplasma gondii and Capillaria hepatica in a ring-tailed lemur is described. As a protozoan parasite, T. gondii can affect nearly all warm-blooded species, causing toxoplasmosis. In lemurs, toxoplasmosis has severe clinical manifestations leading to death. C. hepatica also affects a broad range of mammals, causing hepatic capillariasis. Although it is not known to be lethal, its potential predisposition to toxoplasmosis in our case is of great interest.
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