Articles | Volume 6, issue 1
Primate Biol., 6, 17–58, 2019
https://doi.org/10.5194/pb-6-17-2019
Primate Biol., 6, 17–58, 2019
https://doi.org/10.5194/pb-6-17-2019

Review article 10 May 2019

Review article | 10 May 2019

Experimental autoimmune encephalomyelitis in the common marmoset: a translationally relevant model for the cause and course of multiple sclerosis

Bert A. 't Hart

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The common marmoset (Callithrix jacchus): a relevant preclinical model of human (auto)immune-mediated inflammatory disease of the brain
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Cited articles

Absinta, M., Sati, P., and Reich, D. S.: Advanced MRI and staging of multiple sclerosis lesions, Nat. Rev. Neurol., 12, 358–368, https://doi.org/10.1038/nrneurol.2016.59, 2016. 
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Antunes, S. G., de Groot, N. G., Brok, H., Doxiadis, G., Menezes, A. A., Otting, N., and Bontrop, R. E.: The common marmoset: a new world primate species with limited Mhc class II variability, P. Natl. Acad. Sci. USA, 95, 11745–11750, 1998. 
Araman, C., van Gent, M., Meeuwenoord, N., Heijmans, N., Marqvorsen, H. S., Faber, B. W., 't Hart, B. A., and van Kasteren, S. I.: Amyloid-like behavior of site-specific citrullinated myelin oligodendrocyte protein (MOG) peptide fragments inside EBV infected B-cells influences their cytotoxicity and autoimmunogenicty, Biochemistry, 58, 763–775, https://doi.org/10.1021/acs.biochem.8b00852, 2019. 
Ascherio, A. and Munger, K. L.: Environmental risk factors for multiple sclerosis. Part II: Noninfectious factors, Ann. Neurol., 61, 504–513, 2007. 
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Short summary
Aging Western societies are facing an increasing prevalence of chronic autoimmune-mediated inflammatory disorders (AIMIDs). Animal models have a crucial role in the preclinical research of disease mechanisms and therapy development. Multiple sclerosis is an AIMID specifically affecting the brain and spinal cord. We discuss here a unique MS model in common marmoset monkeys, which has provided novel insights into the disease process as well as into the mechanism of action of new therapies.