Articles | Volume 6, issue 1
Primate Biol., 6, 17–58, 2019
https://doi.org/10.5194/pb-6-17-2019
Primate Biol., 6, 17–58, 2019
https://doi.org/10.5194/pb-6-17-2019
Review article
10 May 2019
Review article | 10 May 2019

Experimental autoimmune encephalomyelitis in the common marmoset: a translationally relevant model for the cause and course of multiple sclerosis

Bert A. 't Hart

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Latest update: 04 Feb 2023
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Short summary
Aging Western societies are facing an increasing prevalence of chronic autoimmune-mediated inflammatory disorders (AIMIDs). Animal models have a crucial role in the preclinical research of disease mechanisms and therapy development. Multiple sclerosis is an AIMID specifically affecting the brain and spinal cord. We discuss here a unique MS model in common marmoset monkeys, which has provided novel insights into the disease process as well as into the mechanism of action of new therapies.