Articles | Volume 4, issue 1
Primate Biol., 4, 107–115, 2017
https://doi.org/10.5194/pb-4-107-2017
© Author(s) 2017. This work is distributed under
the Creative Commons Attribution 3.0 License.
the Creative Commons Attribution 3.0 License.
Special issue: Special diseases of nonhuman primates
Research article 12 Jun 2017
Research article | 12 Jun 2017
Revisiting a quarter of a century of simian immunodeficiency virus (SIV)-associated cardiovascular diseases at the German Primate Center
Matthias Mietsch et al.
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Roland Plesker, Martina Bleyer, and Kerstin Mätz-Rensing
Primate Biol., 5, 7–13, https://doi.org/10.5194/pb-5-7-2018, https://doi.org/10.5194/pb-5-7-2018, 2018
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We present a spontaneous tumor of the meninges (meningioma) in a female pig-tailed macaque (Macaca nemestrina) more than 24 years old. Clinically, the monkey displayed slow, weak, and insecure movements and poor vision. A tumorous mass was present at the floor of the cranial cavity. It compressed adjacent parts of the brain, infiltrated surrounding bones, and expanded into the throat. Microscopically, the tumor showed both meningothelial and microcystic parts.
Kerstin Mätz-Rensing and Martina Bleyer
Primate Biol., 4, 229–230, https://doi.org/10.5194/pb-4-229-2017, https://doi.org/10.5194/pb-4-229-2017, 2017
Kerstin Mätz-Rensing, Constanze Yue, Jeanette Klenner, Heinz Ellerbrok, and Christiane Stahl-Hennig
Primate Biol., 4, 163–171, https://doi.org/10.5194/pb-4-163-2017, https://doi.org/10.5194/pb-4-163-2017, 2017
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The research into therapeutic agents for prevention and treatment of orthopoxvirus (OPXV) infections requires adequate animal models to investigate the efficacy and safety of new vaccines and antiviral compounds against smallpox and other highly pathogenic OPXVs. This study was undertaken to investigate the susceptibility of rhesus monkeys towards the calpox virus, an orthopoxvirus of the species Cowpox virus, which is uniformly lethal in common marmosets, in order to define a new animal model.
Eva Gruber-Dujardin, Martina Bleyer, and Kerstin Mätz-Rensing
Primate Biol., 4, 77–91, https://doi.org/10.5194/pb-4-77-2017, https://doi.org/10.5194/pb-4-77-2017, 2017
Nicole Cichon, Karen Lampe, Felix Bremmer, Tamara Becker, and Kerstin Mätz-Rensing
Primate Biol., 4, 71–75, https://doi.org/10.5194/pb-4-71-2017, https://doi.org/10.5194/pb-4-71-2017, 2017
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We herein report a unique case of granulomatous arteritis in a grey mouse lemur affecting multiple organs, which is not comparable to other disease entities formerly described in nonhuman primates. The features of the entity most closely resemble disseminated visceral giant cell arteritis in humans. A concise description of the disease is given, and the differential diagnoses are discussed. An idiopathic pathogenesis is suspected.
Karen Lampe, Jens-Christian Rudnick, Fabian Leendertz, Martina Bleyer, and Kerstin Mätz-Rensing
Primate Biol., 4, 39–46, https://doi.org/10.5194/pb-4-39-2017, https://doi.org/10.5194/pb-4-39-2017, 2017
Tamara Becker, Florian Pieper, David Liebetanz, Martina Bleyer, Annette Schrod, Kerstin Maetz-Rensing, and Stefan Treue
Primate Biol., 4, 27–32, https://doi.org/10.5194/pb-4-27-2017, https://doi.org/10.5194/pb-4-27-2017, 2017
Martina Bleyer, Marius Kunze, Eva Gruber-Dujardin, and Kerstin Mätz-Rensing
Primate Biol., 4, 17–25, https://doi.org/10.5194/pb-4-17-2017, https://doi.org/10.5194/pb-4-17-2017, 2017
Antonina Klippert, Martina Bleyer, Ulrike Sauermann, Berit Neumann, Artur Kaul, Maria Daskalaki, Nicole Stolte-Leeb, Frank Kirchhoff, and Christiane Stahl-Hennig
Primate Biol., 3, 65–75, https://doi.org/10.5194/pb-3-65-2016, https://doi.org/10.5194/pb-3-65-2016, 2016
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Despite effective antiviral therapy, HIV infection frequently leads to blood cell tumors known as lymphoma in the final disease stage. We have observed the same tumors in monkeys infected with simian immunodeficiency virus. Tumor development coincided with and was fostered by co-infection with the tumorigenic simian homolog to human Epstein–Barr virus. Two cases of lymphoma are presented, one exhibiting an unusual cell surface marker composition and the other obstructing the urogenital tract.
N. Siskos, K. Lampe, F.-J. Kaup, and K. Mätz-Rensing
Primate Biol., 2, 9–12, https://doi.org/10.5194/pb-2-9-2015, https://doi.org/10.5194/pb-2-9-2015, 2015
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In this paper, a co-infection with Toxoplasma gondii and Capillaria hepatica in a ring-tailed lemur is described. As a protozoan parasite, T. gondii can affect nearly all warm-blooded species, causing toxoplasmosis. In lemurs, toxoplasmosis has severe clinical manifestations leading to death. C. hepatica also affects a broad range of mammals, causing hepatic capillariasis. Although it is not known to be lethal, its potential predisposition to toxoplasmosis in our case is of great interest.
Related subject area
Infection biology
Seroprevalence of viral infections in captive rhesus and cynomolgus macaques
Limited susceptibility of rhesus macaques to a cowpox virus isolated from a lethal outbreak among New World monkeys
Wild African great apes as natural hosts of malaria parasites: current knowledge and research perspectives
Detection systems for antibody responses against herpes B virus
Lymphocryptovirus-dependent occurrence of lymphoma in SIV-infected rhesus macaques with particular consideration to two uncommon cases of non-Hodgkin's lymphoma
Prions
Intestinal parasite communities of six sympatric lemur species at Kirindy Forest, Madagascar
Immunodeficiency viruses and prion disease
Artur Kaul, Uwe Schönmann, and Stefan Pöhlmann
Primate Biol., 6, 1–6, https://doi.org/10.5194/pb-6-1-2019, https://doi.org/10.5194/pb-6-1-2019, 2019
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Monitoring macaque health requires the detection of infectious diseases. Here, we report the screening of a macaque colony for antibodies which indicate selected viral infections. Our results show that infection with beta- and gamma-herpesviruses was frequent, while infection with simian retrovirus type D and simian T cell leukemia virus was not. Measles virus infection was more frequent in animals with extensive contact with humans, but no firm correlation could be established.
Kerstin Mätz-Rensing, Constanze Yue, Jeanette Klenner, Heinz Ellerbrok, and Christiane Stahl-Hennig
Primate Biol., 4, 163–171, https://doi.org/10.5194/pb-4-163-2017, https://doi.org/10.5194/pb-4-163-2017, 2017
Short summary
Short summary
The research into therapeutic agents for prevention and treatment of orthopoxvirus (OPXV) infections requires adequate animal models to investigate the efficacy and safety of new vaccines and antiviral compounds against smallpox and other highly pathogenic OPXVs. This study was undertaken to investigate the susceptibility of rhesus monkeys towards the calpox virus, an orthopoxvirus of the species Cowpox virus, which is uniformly lethal in common marmosets, in order to define a new animal model.
Hélène Marie De Nys, Therese Löhrich, Doris Wu, Sébastien Calvignac-Spencer, and Fabian Hubertus Leendertz
Primate Biol., 4, 47–59, https://doi.org/10.5194/pb-4-47-2017, https://doi.org/10.5194/pb-4-47-2017, 2017
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Humans and African great apes (AGAs) are naturally infected with several species of closely related malaria parasites. Research on AGA malaria has been driven by the need to understand the origins of human malaria and the risk of transmission of malaria parasites infecting AGAs to humans. The understanding of the ecology of AGA malaria parasites and their impact on AGA health remains relatively poor. We review current knowledge on AGA malaria and identify gaps and future research perspectives.
Stefan Pöhlmann, Astrid Krüger, Wali Hafezi, Stefan Schneider, Jens Gruber, Michael Winkler, and Artur Kaul
Primate Biol., 4, 9–16, https://doi.org/10.5194/pb-4-9-2017, https://doi.org/10.5194/pb-4-9-2017, 2017
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Transmission of macaque herpes B virus (BV) to humans can induce severe disease. Therefore, diagnostic tests for detecting BV infection are needed. Here, we show that antigens of BV-related non-human primate herpes viruses allow for the detection of antibodies elicited against BV with a higher sensitivity than antigens of human herpes simplex viruses (HSV). Moreover, we provide evidence that using recombinant viral glycoproteins may allow us to discriminate antibody responses against BV and HSV.
Antonina Klippert, Martina Bleyer, Ulrike Sauermann, Berit Neumann, Artur Kaul, Maria Daskalaki, Nicole Stolte-Leeb, Frank Kirchhoff, and Christiane Stahl-Hennig
Primate Biol., 3, 65–75, https://doi.org/10.5194/pb-3-65-2016, https://doi.org/10.5194/pb-3-65-2016, 2016
Short summary
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Despite effective antiviral therapy, HIV infection frequently leads to blood cell tumors known as lymphoma in the final disease stage. We have observed the same tumors in monkeys infected with simian immunodeficiency virus. Tumor development coincided with and was fostered by co-infection with the tumorigenic simian homolog to human Epstein–Barr virus. Two cases of lymphoma are presented, one exhibiting an unusual cell surface marker composition and the other obstructing the urogenital tract.
Walter Bodemer
Primate Biol., 3, 47–50, https://doi.org/10.5194/pb-3-47-2016, https://doi.org/10.5194/pb-3-47-2016, 2016
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Inheritance by DNA and RNA as genetic elements has been known for decades. However, inheritance by proteins was completely unexpected. Proteins as carrier of genetic information have been identified in yeast where non-Mendelian inheritance could not be explained by transfer of chromosomes (DNA). Prions in yeast helped to understand structure and function of mammalian prions. The rhesus monkey has been found to be a valid animal model for prion infection and the epigenetically controlled disease.
Andrea Springer and Peter M. Kappeler
Primate Biol., 3, 51–63, https://doi.org/10.5194/pb-3-51-2016, https://doi.org/10.5194/pb-3-51-2016, 2016
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Parasites play important roles in ecosystems, ultimately by affecting host health and survival. Several host traits generate differences in parasite diversity among host species living in the same habitat. We examine these traits in relation to intestinal parasitism of six sympatric lemur species. We highlight the opportunities of exploring the parasitic fauna of wildlife from a community ecology and evolutionary perspective, and identify avenues for future research on lemur parasitism.
W. Bodemer
Primate Biol., 2, 65–69, https://doi.org/10.5194/pb-2-65-2015, https://doi.org/10.5194/pb-2-65-2015, 2015
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Lentiviral immunodeficiency viruses cause AIDS in humans and in non-human primates. Macaques are a suitable animal model to study infection, disease and the immune response against the retrovirus. As to prion disease, we established a rhesus monkey infection model for this unique infectious pathogen. Animals were experimentally infected with human and bovine prions. Unlike in human prion disease (Creutzfeldt-Jakob disease), we observed early and late stages of disease.
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