Primate Biology
Primate Biology
Primate Biology
Articles | Volume 4, issue 1
Articles | Volume 4, issue 1
https://doi.org/10.5194/pb-4-9-2017
© Author(s) 2017. This work is distributed under
the Creative Commons Attribution 3.0 License.
Special issue:
https://doi.org/10.5194/pb-4-9-2017
© Author(s) 2017. This work is distributed under
the Creative Commons Attribution 3.0 License.
Articles | Volume 4, issue 1
Research article
 | 
17 Feb 2017
Research article |  | 17 Feb 2017

Detection systems for antibody responses against herpes B virus

Stefan Pöhlmann, Astrid Krüger, Wali Hafezi, Stefan Schneider, Jens Gruber, Michael Winkler, and Artur Kaul

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Cited articles

Bailey, C. C. and Miller, A. D.: Ulcerative cheilitis in a rhesus macaque, Vet. Pathol., 49, 412–415, 2012.
Brown, S. M., Ritchie, D. A., and Subak-Sharpe, J. H.: Genetic studies with herpes simplex virus type 1. The isolation of temperature-sensitive mutants, their arrangement into complementation groups and recombination analysis leading to a linkage map, J. Gen. Virol., 18, 329–346, 1973.
Carlson, C. S., O'Sullivan, M. G., Jayo, M. J., Anderson, D. K., Harber, E. S., Jerome, W. G., Bullock, B. C., and Heberling, R. L.: Fatal disseminated cercopithecine herpesvirus 1 (herpes B infection in cynomolgus monkeys (Macaca fascicularis), Vet. Pathol., 34, 405–414, 1997.
Costa, E. A., Luppi, M. M., Malta, M. C., Luiz, A. P., de Araujo, M. R., Coelho, F. M., da Fonseca, F. G., Ecco, R., and Resende, M.: Outbreak of human herpesvirus type 1 infection in nonhuman primates (Callithrix penincillata), J. Wildlife Dis., 47, 690–693, 2011.
Coulibaly, C., Hack, R., Seidl, J., Chudy, M., Itter, G., and Plesker, R.: A natural asymptomatic herpes B virus infection in a colony of laboratory brown capuchin monkeys (Cebus apella), Lab Animal, 38, 432–438, 2004.
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Transmission of macaque herpes B virus (BV) to humans can induce severe disease. Therefore, diagnostic tests for detecting BV infection are needed. Here, we show that antigens of BV-related non-human primate herpes viruses allow for the detection of antibodies elicited against BV with a higher sensitivity than antigens of human herpes simplex viruses (HSV). Moreover, we provide evidence that using recombinant viral glycoproteins may allow us to discriminate antibody responses against BV and HSV.
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Special diseases of nonhuman primates