Articles | Volume 4, issue 1
https://doi.org/10.5194/pb-4-27-2017
© Author(s) 2017. This work is distributed under
the Creative Commons Attribution 3.0 License.
the Creative Commons Attribution 3.0 License.
Special issue:
https://doi.org/10.5194/pb-4-27-2017
© Author(s) 2017. This work is distributed under
the Creative Commons Attribution 3.0 License.
the Creative Commons Attribution 3.0 License.
Research article
| 
07 Mar 2017
Research article |
| 07 Mar 2017
Suspect Guillain-Barré syndrome in a male rhesus macaque (Macaca mulatta)
Tamara Becker
CORRESPONDING AUTHOR
German Primate Center, 37077 Göttingen, Germany
Florian Pieper
German Primate Center, 37077 Göttingen, Germany
David Liebetanz
Georg August University, University Hospital, 37075 Göttingen,
Germany
Martina Bleyer
German Primate Center, 37077 Göttingen, Germany
Annette Schrod
German Primate Center, 37077 Göttingen, Germany
Kerstin Maetz-Rensing
German Primate Center, 37077 Göttingen, Germany
Stefan Treue
German Primate Center, 37077 Göttingen, Germany
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The research into therapeutic agents for prevention and treatment of orthopoxvirus (OPXV) infections requires adequate animal models to investigate the efficacy and safety of new vaccines and antiviral compounds against smallpox and other highly pathogenic OPXVs. This study was undertaken to investigate the susceptibility of rhesus monkeys towards the calpox virus, an orthopoxvirus of the species Cowpox virus, which is uniformly lethal in common marmosets, in order to define a new animal model.
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Despite effective antiviral therapy, HIV infection frequently leads to blood cell tumors known as lymphoma in the final disease stage. We have observed the same tumors in monkeys infected with simian immunodeficiency virus. Tumor development coincided with and was fostered by co-infection with the tumorigenic simian homolog to human Epstein–Barr virus. Two cases of lymphoma are presented, one exhibiting an unusual cell surface marker composition and the other obstructing the urogenital tract.
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In this paper, a co-infection with Toxoplasma gondii and Capillaria hepatica in a ring-tailed lemur is described. As a protozoan parasite, T. gondii can affect nearly all warm-blooded species, causing toxoplasmosis. In lemurs, toxoplasmosis has severe clinical manifestations leading to death. C. hepatica also affects a broad range of mammals, causing hepatic capillariasis. Although it is not known to be lethal, its potential predisposition to toxoplasmosis in our case is of great interest.
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