Articles | Volume 4, issue 2
Primate Biol., 4, 231–240, 2017
https://doi.org/10.5194/pb-4-231-2017

Special issue: Stem cells in non-human primates

Primate Biol., 4, 231–240, 2017
https://doi.org/10.5194/pb-4-231-2017
Research article
20 Nov 2017
Research article | 20 Nov 2017

The ubiquitin ligase c-CBL is expressed in undifferentiated marmoset monkey pluripotent stem cells but is not a general stem cell marker

Ignacio Rodriguez-Polo et al.

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Cited articles

Aeckerle, N., Eildermann, K., Drummer, C., Ehmcke, J., Schweyer, S., Lerchl, A., Bergmann, M., Kliesch, S., Gromoll, J., Schlatt, S., and Behr, R.: The pluripotency factor LIN28 in monkey and human testes: a marker for spermatogonial stem cells?, Mol. Hum. Reprod., 18, 477–488, https://doi.org/10.1093/molehr/gas025, 2012.
Aeckerle, N., Drummer, C., Debowski, K., Viebahn, C., and Behr, R.: Primordial germ cell development in the marmoset monkey as revealed by pluripotency factor expression: suggestion of a novel model of embryonic germ cell translocation, Mol. Hum. Reprod., 21, 66–80, https://doi.org/10.1093/molehr/gau088, 2015.
Debowski, K., Warthemann, R., Lentes, J., Salinas-Riester, G., Dressel, R., Langenstroth, D., Gromoll, J., Sasaki, E., and Behr, R.: Non-viral generation of marmoset monkey iPS cells by a six-factor-in-one-vector approach, PloS one, 10, e0118424, https://doi.org/10.1371/journal.pone.0118424, 2015.
Debowski, K., Drummer, C., Lentes, J., Cors, M., Dressel, R., Lingner, T., Salinas-Riester, G., Fuchs, S., Sasaki, E., and Behr, R.: The transcriptomes of novel marmoset monkey embryonic stem cell lines reflect distinct genomic features, Scientific reports, 6, 29122, https://doi.org/10.1038/srep29122, 2016.
Eildermann, K., Aeckerle, N., Debowski, K., Godmann, M., Christiansen, H., Heistermann, M., Schweyer, S., Bergmann, M., Kliesch, S., Gromoll, J., Ehmcke, J., Schlatt, S., and Behr, R.: Developmental expression of the pluripotency factor sal-like protein 4 in the monkey, human and mouse testis: restriction to premeiotic germ cells, Cells Tissues Organs, 196, 206–220, https://doi.org/10.1159/000335031, 2012.
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Short summary
In some patients with blood cell cancer, the protein c-CBL was found to be mutated. c-CBL has also been shown to be expressed by human testicular stem cells, which produce the spermatozoa. Based on these finding, we asked whether c-CBL may be a protein generally involved in the functioning of stem cells. While we could not detect c-CBL in stem cells of the gut, strong expression was found in pluripotent stem cells (PSCs) of the marmoset monkey, suggesting a role of c-CBL in primate PSCs.