Articles | Volume 4, issue 2
Research article
20 Nov 2017
Research article |  | 20 Nov 2017

The ubiquitin ligase c-CBL is expressed in undifferentiated marmoset monkey pluripotent stem cells but is not a general stem cell marker

Ignacio Rodriguez-Polo, Maike Nielsen, Katharina Debowski, and Rüdiger Behr


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Short summary
In some patients with blood cell cancer, the protein c-CBL was found to be mutated. c-CBL has also been shown to be expressed by human testicular stem cells, which produce the spermatozoa. Based on these finding, we asked whether c-CBL may be a protein generally involved in the functioning of stem cells. While we could not detect c-CBL in stem cells of the gut, strong expression was found in pluripotent stem cells (PSCs) of the marmoset monkey, suggesting a role of c-CBL in primate PSCs.