Articles | Volume 4, issue 2
https://doi.org/10.5194/pb-4-185-2017
© Author(s) 2017. This work is distributed under
the Creative Commons Attribution 4.0 License.
the Creative Commons Attribution 4.0 License.
Special issue:
https://doi.org/10.5194/pb-4-185-2017
© Author(s) 2017. This work is distributed under
the Creative Commons Attribution 4.0 License.
the Creative Commons Attribution 4.0 License.
Review article
| 
11 Oct 2017
Review article |
| 11 Oct 2017
| 11 Oct 2017
Transplantation in the nonhuman primate MPTP model of Parkinson's disease: update and perspectives
Florence Wianny
CORRESPONDING AUTHOR
Univ Lyon, Université Claude Bernard Lyon 1, Inserm, Stem Cell and Brain Research Institute U1208, 69500 Bron, France
Julien Vezoli
CORRESPONDING AUTHOR
Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, 60528 Frankfurt, Germany
Related subject area
Stem cell biology
Baboon induced pluripotent stem cell generation by piggyBac transposition of reprogramming factors
The ubiquitin ligase c-CBL is expressed in undifferentiated marmoset monkey pluripotent stem cells but is not a general stem cell marker
Male germline stem cells in non-human primates
Overcoming barriers to reprogramming and differentiation in nonhuman primate induced pluripotent stem cells
Ignacio Rodriguez-Polo, Michael Stauske, Alexander Becker, Iris Bartels, Ralf Dressel, and Rüdiger Behr
Primate Biol., 6, 75–86, https://doi.org/10.5194/pb-6-75-2019, https://doi.org/10.5194/pb-6-75-2019, 2019
Short summary
Short summary
Stem-cell-based regenerative therapies in patients, e.g., for a failing heart or Parkinson's disease, are within reach. However, studies in appropriate animal models are required to make the final step to the clinic. In this context, the baboon may represent a valuable animal model for specific purposes. Here, we generated five so-called induced pluripotent stem cell lines from the baboon, which may be useful for preclinical testing of the respective therapeutic approaches.
Ignacio Rodriguez-Polo, Maike Nielsen, Katharina Debowski, and Rüdiger Behr
Primate Biol., 4, 231–240, https://doi.org/10.5194/pb-4-231-2017, https://doi.org/10.5194/pb-4-231-2017, 2017
Short summary
Short summary
In some patients with blood cell cancer, the protein c-CBL was found to be mutated. c-CBL has also been shown to be expressed by human testicular stem cells, which produce the spermatozoa. Based on these finding, we asked whether c-CBL may be a protein generally involved in the functioning of stem cells. While we could not detect c-CBL in stem cells of the gut, strong expression was found in pluripotent stem cells (PSCs) of the marmoset monkey, suggesting a role of c-CBL in primate PSCs.
Swati Sharma, Joana M. D. Portela, Daniel Langenstroth-Röwer, Joachim Wistuba, Nina Neuhaus, and Stefan Schlatt
Primate Biol., 4, 173–184, https://doi.org/10.5194/pb-4-173-2017, https://doi.org/10.5194/pb-4-173-2017, 2017
Short summary
Short summary
This review provides an introduction to the in vivo and in vitro germline stem cell terminology and physiology in non-human male primates. Primordial germ cell specification, migration and expansion are compared among species, and the usefulness of pluripotency markers is discussed taking immunohistochemical and molecular evidence during postnatal developmental stages into consideration. The concept of germline plasticity is critically reviewed and might present a primate-specific feature.
Jacob J. Hemmi, Anuja Mishra, and Peter J. Hornsby
Primate Biol., 4, 153–162, https://doi.org/10.5194/pb-4-153-2017, https://doi.org/10.5194/pb-4-153-2017, 2017
Short summary
Short summary
In these studies induced pluripotent stem cells (iPS cells) were generated from donors across the life span of the common marmoset (Callithrix jacchus) and were subjected to a directed neural differentiation protocol. Additionally chimpanzee (Pan troglodytes) iPS cells were generated. Both aged marmoset iPS cells and chimpanzee iPS cells showed defects in their ability to differentiate. However, most of these defects were able to be overcome by a brief treatment with dimethyl sulfoxide.
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Short summary
We propose for this special issue an exhaustive review of past and most recent advances on the topic of cell replacement in Parkinson’s disease, describing the different procedures using transplantation of various cell sources as a therapeutic approach and linked therapeutic behavioral and/or functional outcomes. We conclude by opening perspectives on future promising developments for the use of cell-replacement therapy in research and its translation to the clinic.
We propose for this special issue an exhaustive review of past and most recent advances on the...
Special issue