Primate Biology
Primate Biology
Primate Biology
Articles | Volume 4, issue 2
Articles | Volume 4, issue 2
https://doi.org/10.5194/pb-4-153-2017
© Author(s) 2017. This work is distributed under
the Creative Commons Attribution 3.0 License.
Special issue:
https://doi.org/10.5194/pb-4-153-2017
© Author(s) 2017. This work is distributed under
the Creative Commons Attribution 3.0 License.
Articles | Volume 4, issue 2
Research article
 | 
18 Aug 2017
Research article |  | 18 Aug 2017

Overcoming barriers to reprogramming and differentiation in nonhuman primate induced pluripotent stem cells

Jacob J. Hemmi, Anuja Mishra, and Peter J. Hornsby

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Short summary
In these studies induced pluripotent stem cells (iPS cells) were generated from donors across the life span of the common marmoset (Callithrix jacchus) and were subjected to a directed neural differentiation protocol. Additionally chimpanzee (Pan troglodytes) iPS cells were generated. Both aged marmoset iPS cells and chimpanzee iPS cells showed defects in their ability to differentiate. However, most of these defects were able to be overcome by a brief treatment with dimethyl sulfoxide.
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Stem cells in non-human primates