Articles | Volume 4, issue 2
Primate Biol., 4, 153–162, 2017
https://doi.org/10.5194/pb-4-153-2017

Special issue: Stem cells in non-human primates

Primate Biol., 4, 153–162, 2017
https://doi.org/10.5194/pb-4-153-2017
Research article
18 Aug 2017
Research article | 18 Aug 2017

Overcoming barriers to reprogramming and differentiation in nonhuman primate induced pluripotent stem cells

Jacob J. Hemmi et al.

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Latest update: 05 Dec 2022
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Short summary
In these studies induced pluripotent stem cells (iPS cells) were generated from donors across the life span of the common marmoset (Callithrix jacchus) and were subjected to a directed neural differentiation protocol. Additionally chimpanzee (Pan troglodytes) iPS cells were generated. Both aged marmoset iPS cells and chimpanzee iPS cells showed defects in their ability to differentiate. However, most of these defects were able to be overcome by a brief treatment with dimethyl sulfoxide.