Articles | Volume 4, issue 1
https://doi.org/10.5194/pb-4-131-2017
© Author(s) 2017. This work is distributed under
the Creative Commons Attribution 3.0 License.
the Creative Commons Attribution 3.0 License.
Special issue:
https://doi.org/10.5194/pb-4-131-2017
© Author(s) 2017. This work is distributed under
the Creative Commons Attribution 3.0 License.
the Creative Commons Attribution 3.0 License.
Review article
| 
30 Jun 2017
Review article |
| 30 Jun 2017
Use of nonhuman primates in obstructive lung disease research – is it required?
Franziska Dahlmann
CORRESPONDING AUTHOR
German Primate Center GmbH, Infection Pathology Unit, Kellnerweg 4, 37077
Göttingen, Germany
Fraunhofer Institute for Toxicology and Experimental Medicine, Preclinical
Pharmacology and Immunology, Biomedical Research in Endstage and Obstructive
Lung Disease Hannover (BREATH), Member of the German Center for Lung
Research (DZL), Nikolai-Fuchs-Straße 1, 30625 Hanover, Germany
Katherina Sewald
Fraunhofer Institute for Toxicology and Experimental Medicine, Preclinical
Pharmacology and Immunology, Biomedical Research in Endstage and Obstructive
Lung Disease Hannover (BREATH), Member of the German Center for Lung
Research (DZL), Nikolai-Fuchs-Straße 1, 30625 Hanover, Germany
Related subject area
Immunology
Experimental autoimmune encephalomyelitis in the common marmoset: a translationally relevant model for the cause and course of multiple sclerosis
The common marmoset (Callithrix jacchus): a relevant preclinical model of human (auto)immune-mediated inflammatory disease of the brain
Bert A. 't Hart
Primate Biol., 6, 17–58, https://doi.org/10.5194/pb-6-17-2019, https://doi.org/10.5194/pb-6-17-2019, 2019
Short summary
Short summary
Aging Western societies are facing an increasing prevalence of chronic autoimmune-mediated inflammatory disorders (AIMIDs). Animal models have a crucial role in the preclinical research of disease mechanisms and therapy development. Multiple sclerosis is an AIMID specifically affecting the brain and spinal cord. We discuss here a unique MS model in common marmoset monkeys, which has provided novel insights into the disease process as well as into the mechanism of action of new therapies.
Bert A. 't Hart, Jordon Dunham, S. Anwar Jagessar, and Yolanda S. Kap
Primate Biol., 3, 9–22, https://doi.org/10.5194/pb-3-9-2016, https://doi.org/10.5194/pb-3-9-2016, 2016
Short summary
Short summary
The increasing prevalence of chronic autoimmune inflammatory disorders (AIMIDs) in aging human populations creates a high unmet need for safe and effective medications. However, thus far the translation of pathogenic concepts developed in animal models into effective treatments for the patient has been notoriously difficult. The main reason is that currently used mouse-based animal models for the pipeline selection of promising new treatments were insufficiently predictive for clinical success.
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