Articles | Volume 3, issue 2
Primate Biol., 3, 65–75, 2016
https://doi.org/10.5194/pb-3-65-2016

Special issue: 3R issues and immunosuppression in non-human primates

Primate Biol., 3, 65–75, 2016
https://doi.org/10.5194/pb-3-65-2016

Research article 20 Dec 2016

Research article | 20 Dec 2016

Lymphocryptovirus-dependent occurrence of lymphoma in SIV-infected rhesus macaques with particular consideration to two uncommon cases of non-Hodgkin's lymphoma

Antonina Klippert et al.

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Cited articles

Armitage, J. O. and Weisenburger, D. D.: New approach to classifying non-Hodgkin's lymphomas: clinical features of the major histologic subtypes. Non-Hodgkin's Lymphoma Classification Project, J. Clin. Oncol., 16, 2780–2795, 1998.
Bates, A. W., Norton, A. J., and Baithun, S. I.: Malignant lymphoma of the urinary bladder: a clinicopathological study of 11 cases, J. Clin. Pathol., 53, 458–461, 2000.
Blaschke, S., Hannig, H., Buske, C., Kaup, F. J., Hunsmann, G., and Bodemer, W.: Expression of the simian Epstein-Barr virus-encoded latent membrane protein-1 in malignant lymphomas of SIV-infected rhesus macaques, J. Med. Virol., 65, 114–120, 2001.
Chen, W. L., Tsai, W. C., Chao, T. Y., Sheu, L. F., Chou, J. M., Kao, W. Y., Chen, Y. C., and Ho, C. L.: The clinicopathological analysis of 303 cases with malignant lymphoma classified according to the World Health Organization classification system in a single institute of Taiwan, Ann. Hematol., 89, 553–562, https://doi.org/10.1007/s00277-009-0870-z, 2010.
Chmielewicz, B., Goltz, M., Lahrmann, K. H., and Ehlers, B.: Approaching virus safety in xenotransplantation: a search for unrecognized herpesviruses in pigs, Xenotransplantation, 10, 349–356, 2003.
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Short summary
Despite effective antiviral therapy, HIV infection frequently leads to blood cell tumors known as lymphoma in the final disease stage. We have observed the same tumors in monkeys infected with simian immunodeficiency virus. Tumor development coincided with and was fostered by co-infection with the tumorigenic simian homolog to human Epstein–Barr virus. Two cases of lymphoma are presented, one exhibiting an unusual cell surface marker composition and the other obstructing the urogenital tract.