Articles | Volume 2, issue 1
Primate Biol., 2, 65–69, 2015

Special issue: Hans-Jürg Kuhn and the German Primate Center

Primate Biol., 2, 65–69, 2015

Review article 24 Aug 2015

Review article | 24 Aug 2015

Immunodeficiency viruses and prion disease

W. Bodemer

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Cited articles

Andrieu, J. M., Chen, S., Lai, C., Guo, W., and Lu, W.: Mucosal SIV vaccines comprising inactivated virus particles and bacterial adjuvants induce CD8(+) T-regulatory cells that suppress SIV-positive CD4(+) T-cell activation and prevent SIV infection in the Macaque model, Front Immunol., 5, 297,, 2014.
Asante, E. A., Smidak, M., Grimshaw, A., Houghton, R., Tomlinson, A., Jeelani, A., Jakubcova, T., Hamdan, S., Richard-Londt, A., Linehan, J. M., Brandner, S., Alpers, M., Whitfield, J., Mead, S., Wadsworth, J. D., and Collinge, J.: A naturally occurring variant of the human prion protein completely prevents prion disease, Nature, 522, 478–481,, 2015.
Bodemer, W.: Prions, in: Encyclopedia of Microbiology 3rd Edn., edited by: Schaechter, M., Academic Press, 689–706, 2009.
Krasemann, S., Mearini, G., Krämer, E., Wagenführ, K., Schulz-Schaeffer, W., Neumann, M., Bodemer, W., Kaup, F. J., Beekes, M., Carrier, L., Aguzzi, A., and Glatzel, M.: BSE-associated prion-amyloid cardiomyopathy in primates, Emerg Infect Dis., 19, 985–988,, 2013.
Short summary
Lentiviral immunodeficiency viruses cause AIDS in humans and in non-human primates. Macaques are a suitable animal model to study infection, disease and the immune response against the retrovirus. As to prion disease, we established a rhesus monkey infection model for this unique infectious pathogen. Animals were experimentally infected with human and bovine prions. Unlike in human prion disease (Creutzfeldt-Jakob disease), we observed early and late stages of disease.