Articles | Volume 2, issue 1
Primate Biol., 2, 65–69, 2015
https://doi.org/10.5194/pb-2-65-2015

Special issue: Hans-Jürg Kuhn and the German Primate Center

Primate Biol., 2, 65–69, 2015
https://doi.org/10.5194/pb-2-65-2015

Review article 24 Aug 2015

Review article | 24 Aug 2015

Immunodeficiency viruses and prion disease

W. Bodemer

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Cited articles

Andrieu, J. M., Chen, S., Lai, C., Guo, W., and Lu, W.: Mucosal SIV vaccines comprising inactivated virus particles and bacterial adjuvants induce CD8(+) T-regulatory cells that suppress SIV-positive CD4(+) T-cell activation and prevent SIV infection in the Macaque model, Front Immunol., 5, 297, https://doi.org/10.3389/fimmu.2014.00297, 2014.
Asante, E. A., Smidak, M., Grimshaw, A., Houghton, R., Tomlinson, A., Jeelani, A., Jakubcova, T., Hamdan, S., Richard-Londt, A., Linehan, J. M., Brandner, S., Alpers, M., Whitfield, J., Mead, S., Wadsworth, J. D., and Collinge, J.: A naturally occurring variant of the human prion protein completely prevents prion disease, Nature, 522, 478–481, https://doi.org/10.1038/nature14510, 2015.
Bodemer, W.: Prions, in: Encyclopedia of Microbiology 3rd Edn., edited by: Schaechter, M., Academic Press, 689–706, 2009.
Krasemann, S., Mearini, G., Krämer, E., Wagenführ, K., Schulz-Schaeffer, W., Neumann, M., Bodemer, W., Kaup, F. J., Beekes, M., Carrier, L., Aguzzi, A., and Glatzel, M.: BSE-associated prion-amyloid cardiomyopathy in primates, Emerg Infect Dis., 19, 985–988, https://doi.org/10.3201/eid1906.120906, 2013.
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Short summary
Lentiviral immunodeficiency viruses cause AIDS in humans and in non-human primates. Macaques are a suitable animal model to study infection, disease and the immune response against the retrovirus. As to prion disease, we established a rhesus monkey infection model for this unique infectious pathogen. Animals were experimentally infected with human and bovine prions. Unlike in human prion disease (Creutzfeldt-Jakob disease), we observed early and late stages of disease.