Articles | Volume 9, issue 2
Short communication
27 Jul 2022
Short communication |  | 27 Jul 2022

The use of alfaxalone for short-term anesthesia can confound serum progesterone measurements in the common marmoset: a case report

Maria Daskalaki, Charis Drummer, Rüdiger Behr, and Michael Heistermann

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Cited articles

Abouelfetouh, M. M., Liu, L., Salah, E., Sun, R., Nan, S., Ding, M., and Ding, Y.: The Effect of Xylazine Premedication on the Dose and Quality of Anesthesia Induction with Alfaxalone in Goats, Animals (Basel), 11, 723,, 2021. 
Albertson, T. E., Walby, W. F., and Joy, R. M.: Modification of GABA-mediated inhibition by various injectable anesthetics, Anesthesiology, 77, 488–499,, 1992. 
Andaluz, A., Felez-Ocana, N., Santos, L., Fresno, L., and Garcia, F.: The effects on cardio-respiratory and acid-base variables of the anaesthetic alfaxalone in a 2-hydroxypropyl-beta-cyclodextrin (HPCD) formulation in sheep, Vet. J., 191, 389–392,, 2012. 
Andaluz, A., Santos, L., Garcia, F., Ferrer, R. I., Fresno, L., and Moll, X.: Maternal and foetal cardiovascular effects of the anaesthetic alfaxalone in 2-hydroxypropyl-beta-cyclodextrin in the pregnant ewe, Sci. World J., 2013, 189843,, 2013. 
Bakker, J., Uilenreef, J. J., Pelt, E. R., Brok, H. P., Remarque, E. J., and Langermans, J. A.: Comparison of three different sedative-anaesthetic protocols (ketamine, ketamine-medetomidine and alphaxalone) in common marmosets (Callithrix jacchus), BMC Vet. Res., 9, 113,, 2013. 
Short summary
Alfaxalone is a general anesthetic used widely in veterinary medicine and has a chemical structure similar to progesterone. Here we report an unexpectedly high serum progesterone value in a female common marmoset following the treatment with alfaxalone. Cross-reactivity of the antibody used in the progesterone assay with alfaxalone most likely explains this finding, and therefore evaluation of serum progesterone results in animals treated with alfaxalone should be done with caution.