Articles | Volume 4, issue 2
https://doi.org/10.5194/pb-4-173-2017
© Author(s) 2017. This work is distributed under
the Creative Commons Attribution 3.0 License.
the Creative Commons Attribution 3.0 License.
Special issue:
https://doi.org/10.5194/pb-4-173-2017
© Author(s) 2017. This work is distributed under
the Creative Commons Attribution 3.0 License.
the Creative Commons Attribution 3.0 License.
Review article
| 
22 Sep 2017
Review article |
| 22 Sep 2017
Male germline stem cells in non-human primates
Swati Sharma
Center of Reproductive Medicine and Andrology, Institute of
Reproductive and Regenerative Medicine, Albert Schweitzer Campus 1, Building
D11, Münster, Germany
Joana M. D. Portela
Center for Reproductive Medicine, Academic Medical Center,
University of Amsterdam, 1105 AZ Amsterdam, the Netherlands
Daniel Langenstroth-Röwer
Center of Reproductive Medicine and Andrology, Institute of
Reproductive and Regenerative Medicine, Albert Schweitzer Campus 1, Building
D11, Münster, Germany
Joachim Wistuba
Center of Reproductive Medicine and Andrology, Institute of
Reproductive and Regenerative Medicine, Albert Schweitzer Campus 1, Building
D11, Münster, Germany
Nina Neuhaus
Center of Reproductive Medicine and Andrology, Institute of
Reproductive and Regenerative Medicine, Albert Schweitzer Campus 1, Building
D11, Münster, Germany
Stefan Schlatt
CORRESPONDING AUTHOR
Center of Reproductive Medicine and Andrology, Institute of
Reproductive and Regenerative Medicine, Albert Schweitzer Campus 1, Building
D11, Münster, Germany
Related authors
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S. Irfan, J. Wistuba, J. Ehmcke, M. Shahab, and S. Schlatt
Primate Biol., 2, 1–8, https://doi.org/10.5194/pb-2-1-2015, https://doi.org/10.5194/pb-2-1-2015, 2015
Related subject area
Stem cell biology
Baboon induced pluripotent stem cell generation by piggyBac transposition of reprogramming factors
The ubiquitin ligase c-CBL is expressed in undifferentiated marmoset monkey pluripotent stem cells but is not a general stem cell marker
Transplantation in the nonhuman primate MPTP model of Parkinson's disease: update and perspectives
Overcoming barriers to reprogramming and differentiation in nonhuman primate induced pluripotent stem cells
Ignacio Rodriguez-Polo, Michael Stauske, Alexander Becker, Iris Bartels, Ralf Dressel, and Rüdiger Behr
Primate Biol., 6, 75–86, https://doi.org/10.5194/pb-6-75-2019, https://doi.org/10.5194/pb-6-75-2019, 2019
Short summary
Short summary
Stem-cell-based regenerative therapies in patients, e.g., for a failing heart or Parkinson's disease, are within reach. However, studies in appropriate animal models are required to make the final step to the clinic. In this context, the baboon may represent a valuable animal model for specific purposes. Here, we generated five so-called induced pluripotent stem cell lines from the baboon, which may be useful for preclinical testing of the respective therapeutic approaches.
Ignacio Rodriguez-Polo, Maike Nielsen, Katharina Debowski, and Rüdiger Behr
Primate Biol., 4, 231–240, https://doi.org/10.5194/pb-4-231-2017, https://doi.org/10.5194/pb-4-231-2017, 2017
Short summary
Short summary
In some patients with blood cell cancer, the protein c-CBL was found to be mutated. c-CBL has also been shown to be expressed by human testicular stem cells, which produce the spermatozoa. Based on these finding, we asked whether c-CBL may be a protein generally involved in the functioning of stem cells. While we could not detect c-CBL in stem cells of the gut, strong expression was found in pluripotent stem cells (PSCs) of the marmoset monkey, suggesting a role of c-CBL in primate PSCs.
Florence Wianny and Julien Vezoli
Primate Biol., 4, 185–213, https://doi.org/10.5194/pb-4-185-2017, https://doi.org/10.5194/pb-4-185-2017, 2017
Short summary
Short summary
We propose for this special issue an exhaustive review of past and most recent advances on the topic of cell replacement in Parkinson’s disease, describing the different procedures using transplantation of various cell sources as a therapeutic approach and linked therapeutic behavioral and/or functional outcomes. We conclude by opening perspectives on future promising developments for the use of cell-replacement therapy in research and its translation to the clinic.
Jacob J. Hemmi, Anuja Mishra, and Peter J. Hornsby
Primate Biol., 4, 153–162, https://doi.org/10.5194/pb-4-153-2017, https://doi.org/10.5194/pb-4-153-2017, 2017
Short summary
Short summary
In these studies induced pluripotent stem cells (iPS cells) were generated from donors across the life span of the common marmoset (Callithrix jacchus) and were subjected to a directed neural differentiation protocol. Additionally chimpanzee (Pan troglodytes) iPS cells were generated. Both aged marmoset iPS cells and chimpanzee iPS cells showed defects in their ability to differentiate. However, most of these defects were able to be overcome by a brief treatment with dimethyl sulfoxide.
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Short summary
This review provides an introduction to the in vivo and in vitro germline stem cell terminology and physiology in non-human male primates. Primordial germ cell specification, migration and expansion are compared among species, and the usefulness of pluripotency markers is discussed taking immunohistochemical and molecular evidence during postnatal developmental stages into consideration. The concept of germline plasticity is critically reviewed and might present a primate-specific feature.
This review provides an introduction to the in vivo and in vitro germline stem cell terminology...
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