Articles | Volume 4, issue 2
Review article
22 Sep 2017
Review article |  | 22 Sep 2017

Male germline stem cells in non-human primates

Swati Sharma, Joana M. D. Portela, Daniel Langenstroth-Röwer, Joachim Wistuba, Nina Neuhaus, and Stefan Schlatt

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Cited articles

Aeckerle, N., Eildermann, K., Drummer, C., Ehmcke, J., Schweyer, S., Lerchl, A., Bergmann, M., Kliesch, S., Gromoll, J., Schlatt, S., and Behr, R.: The pluripotency factor LIN28 in monkey and human testes: a marker for spermatogonial stem cells?, Mol. Hum. Reprod., 18, 477–488, 2012.
Aeckerle, N., Drummer, C., Debowski, K., Viebahn, C., and Behr R.: Primordial germ cell development in the marmoset monkey as revealed by pluripotency factor expression: suggestion of a novel model of embryonic germ cell translocation, Mol. Hum. Reprod., 21, 66–80, 2015.
Albert, S., Wistuba, J., Eildermann, K., Ehmcke, J., Schlatt, S., Gromoll, J., and Kossack N.: Comparative marker analysis after isolation and culture of testicular cells from the immature marmoset, Cells Tissues Organs, 196, 543–554, 2012.
Albert, S., Ehmcke, J., Wistuba, J., Eildermann, K., Behr, R., Schlatt, S., and Gromoll J.: Germ cell dynamics in the testis of the postnatal common marmoset monkey (Callithrix jacchus), Reproduction, 140, 733–742, 2010.
Anderson, R. A., Fulton, N., Cowan, G., Coutts, S., and Saunders, P. T.: Conserved and divergent patterns of expression of DAZL, VASA and OCT4 in the germ cells of the human fetal ovary and testis, BMC Dev. Biol., 7, 136, 2007.
Short summary
This review provides an introduction to the in vivo and in vitro germline stem cell terminology and physiology in non-human male primates. Primordial germ cell specification, migration and expansion are compared among species, and the usefulness of pluripotency markers is discussed taking immunohistochemical and molecular evidence during postnatal developmental stages into consideration. The concept of germline plasticity is critically reviewed and might present a primate-specific feature.