Articles | Volume 3, issue 2
https://doi.org/10.5194/pb-3-47-2016
https://doi.org/10.5194/pb-3-47-2016
Review article
 | 
07 Sep 2016
Review article |  | 07 Sep 2016

Prions

Walter Bodemer

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Short summary
Inheritance by DNA and RNA as genetic elements has been known for decades. However, inheritance by proteins was completely unexpected. Proteins as carrier of genetic information have been identified in yeast where non-Mendelian inheritance could not be explained by transfer of chromosomes (DNA). Prions in yeast helped to understand structure and function of mammalian prions. The rhesus monkey has been found to be a valid animal model for prion infection and the epigenetically controlled disease.